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Sep 11 2023

9/11 – Xiaoyang Wu, University of Chicago

CBQB Seminar (in-person event)

September 11, 2023

12:00 PM - 1:30 PM


CBQB Seminar in COMRB 8175


909 S Wolcott Ave, Chicago, IL 60612

This is an in-person event in room COMRB 8175 on west campus (directions).  You can also watch seminar live here>>


Xiaoyang Wu
Associate Professor
Ben May Department of Cancer Research
University of Chicago


Somatic stem cell and biomaterial engineering for skin disease and beyond


Somatic gene therapy provides a promising therapeutic approach for a variety of otherwise terminal or severely disabling diseases. We have developed a novel cutaneous gene transfer approach by combining genome editing technology with the skin epidermal system. In proof-of-concept studies, we have demonstrated that we can develop engineered skin epidermal stem cells to achieve stable and long term delivery of incretin hormone GLP1 in vivo, which can significantly reduce body weight and help maintain glucose homeostasis. Additionally, by engineering skin somatic stem cells, we demonstrated the tempting possibility that we can deliver a therapeutic protein, hBChE, which can effectively protect against cocaine-seeking and overdose in vivo. The clinical potential of cutaneous gene transfer is broad, and our research has established the essential groundwork and tools for this rapidly evolving field.


UIC Biomedical Engineering

Date posted

Aug 31, 2023

Date updated

Jan 2, 2024