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Nov 27 2023

11/27 – Yuan-Nan Young Professor, New Jersey Institute of Technology

CBQB Seminar (in-person event)

November 27, 2023

12:00 PM - 1:00 PM


CBQB Seminar in COMRB 8175


909 S Wolcott Ave, Chicago, IL 60612

This is an in-person event in room COMRB 8175 on west campus (directions).  You can also watch seminar live here>>


Yuan-Nan Young
Professor, Mathematical Sciences
New Jersey Institute of Technology


Stoichiometric Model for the Microtubule-mediated dynamics of centrosome and nucleus


The Stoichiometric Model for the interaction of centrosomes with cortically anchored pulling motors, through their associated microtubules (MTs), has been applied to study key steps in the cell division such as spindle positioning and elongation. In this work we extend the original Stoichiometric Model to incorporate (1) overlap in the cortical motors, and (2) the dependence of velocity in the detachment rate of MTs from the cortical motors. We examine the effects of motor overlap and velocity-dependent detachment rate on the centrosome dynamics, such as the radial oscillation around the geometric center of the cell, the nonlinear nature (supercritical and subcritical Hopf bifurcation) of such oscillation, and the nonlinear orbital motions previously found for a centrosome. We explore biologically feasible parameter regimes where these effects may lead to significantly different centrosome/nucleus dynamics. Furthermore we use this extended Stoichiometric Model to study the migration of a nucleus being positioned by a centrosome. This is joint work with Justin Maramuthal, Reza Farhadifar and Michael Shelley.


UIC Biomedical Engineering

Date posted

Oct 26, 2023

Date updated

Jan 2, 2024