8/24 – Heungsoo Shin, Hanyang University, Seoul, South Korea
August 24, 2022
12:00 PM - 1:00 PM
COMRB 2175 (in-person event on WEST Campus)
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This is an in person event in room COMRB 2175 (West Campus).
Speaker: Heungsoo Shin, Ph.D.
Professor, Department of Bioengineering,Hanyang University, Seoul, South Korea.
Title: Biomaterials-based delivery of signaling molecules and cells for tissue engineering and regenerative medicine
Abstract: Tissue engineering and regenerative medicine have gained considerable interest in recent years due to the potential to treat patients with chronic or degenerative diseases. For example, bone fracture associated with increase in patients with osteoporosis and other injuries becomes one of the large clinical problems, which requires tissue engineering strategy because of limited supply of graft materials. Tissue healing is complex processes involving regulation of inflammatory response after injury, migration, tissue-specific induction of uncommitted mesenchymal stem cells, and remodelling of loosely formed pre-mature tissue. Therefore, it is of importance to consider engineering approaches to regulate multi-facet processes of these tissue healing events. Given that, we have been developing biomaterials as carriers of various cell-instructive signals or stem cells to actively guide tissue regeneration. For example, biomaterials with controlled substrate-mediated delivery of proteins, peptide, or small molecules have been developed to enhance osteogenesis of stem cells and suppression of inflammatory response. The combination of stem cells with these materials have been used to engineer multi-cellular composite 3D spheroids for the fabrication of structurally and functionally reliable in vitro artificial 3D tissues. In addition, strategies for encapsulation of spheroids within biocompatible hydrogels have been explored for recapitulation of cellular microenvironment of engineered tissue of the desired shape with enhanced specific biological functions. This presentation will summarize and discuss our endeavour to engineer biomaterials in regard to how we design them enabling delivery of stem cells and signaling molecules, in particular for regeneration of bone tissue.
Aug 9, 2022
Aug 24, 2022