8/22 – John Straub, Boston University
CBQB Seminar
August 22, 2022
12:00 PM - 1:30 PM
Location
COMBR 7175 (in-person event)
Address
909 S Wolcott Ave, Chicago, IL 60612
Calendar
Download iCal FileThis is an in person event in room COMRB 7175 (909 S Wolcott Ave, Chicago, IL 60612 on west campus). You can also watch seminar live here>>
Speaker: Dr. John Straub
Professor, Boston University
Title: Probing the principles governing amyloid, protein aggregation and fibril formation
Abstract: Considerable progress has been made, using experiments and computations, to decipher the general principles governing the mechanism of formation of oligomers and fibrils of amyloid proteins implicated in diseases. The formation of amyloid aggregates is often observed to proceed from intrinsically disordered protein monomers to a highly ordered fibrillar state. Moreover, changes in sequence and environment may lead to a variety of polymorphs of the fibril state. I will discuss recent work exploring the connection between the conformational distribution of the monomeric protein and the ultimate fibril state. Examples will be taken from studies of amyloid-β protein (Aβ), associated with Alzheimer’s disease (AD), Fused in Sarcoma (FUS) protein, implicated in ALS and liquid-liquid phase separation, and Serum Amyloid A (SAA) protein, associated with AA amyloidosis.
Date posted
Aug 15, 2022
Date updated
Aug 19, 2022