4/8 – Brian Aguado, UCSD
April 8, 2022
12:00 PM - 1:00 PM
Location
SEO 236 (in person event)
Address
851 S. Morgan St, Chicago, IL 60607
Calendar
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Speaker: Brian Aguado, Assistant Professor of Bioengineering, University of California, San Diego
Title: Sex-specific in vitro models of aortic valve stenosi
Abstract: Cardiovascular disease is the leading cause of death in both men and women, yet our mechanistic knowledge of the sex-specific molecular and cellular mechanisms that guide cardiovascular disease progression, particularly in women, remain poorly characterized. Studies evaluating disease mechanisms rarely state the sex of cells used for in vitro studies or are performed primarily in male animal models, causing our gap in knowledge. My laboratory uses precision biomaterials as in vitro and in vivo tools to dissect mechanisms that contribute to sexual dimorphisms in cardiovascular diseases, specifically aortic valve stenosis. In my talk, I will discuss how we have used hydrogel biomaterials as engineered valve matrix mimics to explore sex dimorphisms in valvular interstitial cell phenotypes in vitro and describe sex-specific molecular mechanisms that may drive dimorphisms in aortic valve stenosis. Our work seeks to leverage biomaterial technologies to understand sex dimorphisms in health and disease, with the long-term goal of achieving sex and gender equity in cardiovascular disease treatments and outcomes.
Date posted
Mar 11, 2022
Date updated
Mar 11, 2022