4/29 – Shankar Subramaniam, UCSD
April 29, 2022
12:00 PM - 1:00 PM
Location
COMRB 1020 (in person event on WEST Campus)
Address
909 S Wolcott Ave, Chicago, IL 60612
Calendar
Download iCal FileThis is an in person event in room 1020 COMRB, 909 S Wolcott Ave, Chicago IL 60612.
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Speaker: Shankar Subramaniam, PhD
Distinguished Professor of Bioengineering & Systems Biology, Computer Science & Engineering, Cellular & Molecular Medicine, Nanoengineering, & Bioinformatics & Systems Biology Program, University of California, San Diego
Title: Alzheimer’s Disease: A Grand Challenge at the Interface of Engineering, Medicine, and Biology
Abstract: Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with development of novel engineering methods and technologies. In this talk I will focus on systems and engineering approaches to a major health care need of diagnosis and treatment of Alzheimer’s disease. Alzheimer’s disease is a debilitating disease that afflicts six million people in the United States and has no successful treatment. While cognitive measurements are often the diagnostic indicators followed by various live brain imaging, the diagnoses come too late and clinical trials over two decades on treatments have failed. In this talk, I will identify the challenges in investigating Alzheimer’s disease and outline how recent technologies and analytics strategies can help in paving the way for early diagnosis and in designing novel treatments.
Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer’s disease. Alzheimers and Dementia 2022. 1–14. DOI: 10.1002/alz.12553.
Caldwell AB, Liu Q, Schroth GP, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. Dedifferentiation and neuronal repression define familial Alzheimer's disease. Sci Adv. 2020 Nov 13;6(46):eaba5933. doi: 10.1126/sciadv.aba5933. PMID: 33188013; PMCID: PMC7673760.
Date posted
Apr 11, 2022
Date updated
Apr 19, 2022