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Jan 14 2022

1/14 – Thomas J. Royston, University of Illinois Chicago

Biomedical Engineering Seminar

January 14, 2022

12:00 PM - 1:00 PM


Chicago, IL

Watch this seminar live here>>

Speaker: Thomas J. Royston, PhD

Professor and Department Head
Richard & Loan Hill Biomedical Engineering
University of Illinois Chicago

Title: The Combined Importance of Finite Dimensions, Anisotropy, and Pre-stress in Acousto-elastography

Dynamic elastography, whether based on magnetic resonance, ultrasound or optical modalities, attempts to reconstruct quantitative maps of the viscoelastic properties of biological tissue, properties that are altered by disease and injury, by noninvasively measuring mechanical wave motion in the tissue. Most reconstruction strategies that have been developed neglect boundary conditions, including quasistatic tensile or compressive loading resulting in a nonzero prestress. Significant prestress is inherent to the functional role of some biological tissues currently being studied using elastography, such as skeletal and cardiac muscle, arterial walls, and the cornea. In the present article we review how prestress alters both bulk mechanical wave motion and wave motion in one- and two-dimensional waveguides. Key findings are linked to studies on skeletal muscle and the human cornea, as one- and two- dimensional waveguide examples. This study highlights the underappreciated combined acoustoelastic and waveguide challenge to elastography. Can elastography truly determine viscoelastic properties of a material when what it is measuring is affected by both these material properties and unknown prestress and other boundary conditions?


UIC Biomedical Engineering

Date posted

Jan 12, 2022

Date updated

Jan 12, 2022