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UID:2026100905182520250307T11000020250307T1140006ac921e1a97e0@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20250124T101135Z
DTSTART:20250307T110000
DTEND:20250307T114000
SUMMARY:3/7 - Elisa Budyn\, UIC\, Universite Paris-Saclay
DESCRIPTION:Speaker:    Elisa Budyn\, Ph.D.    Adjunct Professor  Mechanical Engineering\, Oral Medicine and Diagnostic Sciences  University of Illinois at Chicago  Professor PU\, DrHab\, PhD\, MS\, TP98Université Paris-Saclay  CentraleSupelec - ENS Paris-Saclay  Mechanical Engineering - CNRS Laboratory of Mechanics Paris-Saclay    Title: Working with human in vitro systems in the framework of animal-free research      Abstract:    CNRS Laboratory of Mechanics Paris-Saclay\, Ecole Normale Superieure Paris-Saclay\, Gif-sur Yvette\, F-91190.    Animals have been used for a very long time in Bioengineering. While animal models make it possible to work with many individuals that are precisely characterized\, the results are sometimes difficult to translate to humans. While developing in vivo human models include many challenges\, human in vitro models offer a nice compromise.    In working with human models\, the number of samples may be limited\, specific legal regulations have to be respected\, ensuring reliable supplies and implementing models in facilities approved for culturing human tissues. Compared to animal models\, human in vitro models must also recreate an environment as close as possible to in vivo conditions to encompass the limitation of not having a complete living organism.    Because human tissue morphologies are highly complex and human cell behavior are more complicated than many mammals\, advanced 3D imaging techniques such micro or nano CT as well as fluorescent confocal microscopy are necessary to understand human tissues and organoid microstructures\, and to accurately follow cell biology. Complementary techniques such as nanoindentation or spectroscopies can measure and identify the different material components. The mechanical properties can also be measured by miniaturized mechanical tests. Because in vitro systems are alive\, mechanical stimulations can drive human cells to their proper differentiation and biology\, approaching in vivo conditions. Finally\, cell biology can be verified by transcriptomics using qPCR to quantify the expressed mRNA which in turn can be correlated to the cell secretome.    This procedure using organ-on-chip techniques has been applied to study aging and pathology effects on bone\, or to study the effects of regenerative medicines in the intervertebral disc\, or to evaluate the effect of the interaction between different implants and the hip capsule ligament. | Event post: https://bme.uic.edu/events?page_id=9861
LOCATION:BME Seminar in SEO 236 851 S Morgan St  Chicago IL 60607
CLASS:PRIVATE
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