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PRODID:-//UIC
BEGIN:VEVENT
UID:2026100905462820260220T11000020260220T1200006ac92874d9769@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20251230T232037Z
DTSTART:20260220T110000
DTEND:20260220T120000
SUMMARY:2/20 - Xilal Y. Rima\, The Ohio State University
DESCRIPTION:Speaker:    Xilal Y. Rima\, PhD    NIH T32 Cardiometabolic Science Program Postdoctoral Fellow    Department of Internal Medicine\, Division of Endocrinology\, Diabetes\, and Metabolism    The Ohio State University Wexner Medical Center        Title: Uncovering the Role of Adipocyte-Derived Extracellular Vesicles in Obesity      Abstract: Obesity is on the rise\, with 51% of the global population predicted to be overweight or obese by 2035. In addition to serving as a metabolic cell\, the adipocyte\, the primary cell in adipose tissue\, promotes inflammation through innate and adaptive immune functions. Yet\, the process by which this locoregional inflammation influences distal inflammatory responses remains unknown. In this seminar\, I will describe the role of adipocyte-derived extracellular vesicles (EVs) in relaying inflammatory signals to distal organs and accelerating various obesity-associated diseases. Adipocyte-derived EVs from lean and obese subjects produce differential physiological effects in mice and proinflammatory effects in human cells\, linked to molecular differences in EV cargo. However\, EV cargo is highly heterogeneous\, and conventional bulk-analysis methods overlook the complexity of EVs. To gain insight into the heterogeneity of adipocyte-derived EVs\, the second part of the seminar will introduce various surface engineering techniques to probe EVs at the single-particle level for applications such as digital titrations\, colocalization analyses\, cell-functional assays\, immunogold labeling\, and correlating optical and non-optical techniques. This work establishes a connection between adipocyte inflammation and obesity-associated diseases and highlights an opportunity for engineering approaches to provide care for a growing patient population. | Event post: https://bme.uic.edu/events?page_id=10697
LOCATION:BME Seminar in SEO 236 851 S Morgan St  Chicago IL 60607
CLASS:PRIVATE
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