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PRODID:-//UIC
BEGIN:VEVENT
UID:2026051102225020251010T11000020251010T1200006a013d7a9afe3@uic.edu
CATEGORIES:MEETING
STATUS:TENTATIVE
DTSTAMP:20250821T023737
DTSTART:20251010T110000
DTEND:20251010T120000
SUMMARY:10/10 - Hao F. Zhang, Northwestern University
DESCRIPTION:Speaker:      Hao F. Zhang, Ph.D.  Professor  Department of Biomedical Engineering  Northwestern University    Title: Combining super-resolution microscopy and optical coherence tomography for multi-scale imaging      Abstract: My group focuses on two core technologies, spectroscopic single-molecule localization microscopy (sSMLM) and visible-light optical coherence tomography (vis-OCT), and their applications to vision and cancer imaging at the length scale ranging from single molecules to whole human eyes. While traditional OCT uses near-infrared light, vis-OCT leverages the significantly higher tissue contrast within the visible light spectral range to extract physiological and pathological information, in addition to ultra-high (1.3 µm) resolution anatomical imaging. Using vis-OCT in both patients and small animal models, we detected retinal ischemia well before the onset of angiogenesis, produced the first in vivo three-dimensional imaging of the entire ocular outflow pathway, and discovered new biomarkers of neuronal damage. In contrast, sSMLM offers multiplex super-resolution imaging with a spatial resolution of up to 1 nm by analyzing the spatial locations and full fluorescence emission spectra of stochastic single-molecule fluorescence emissions. Using sSMLM, we overcame the long-standing challenges of rejecting fluorescence impurities, investigated single-molecule fluorescence heterogeneities, and imaged molecular interactions with drastically different molecular concentrations. In this talk, I will describe the working principles of vis-OCT and sSMLM and how we combine them to investigate multiple blinding diseases, especially glaucoma, comprehensively. | Event post: https://bme.uic.edu/events?page_id=10371
LOCATION:BME Seminar in SEO 236 851 S Morgan St  Chicago IL 60607
CLASS:PRIVATE
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