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Aug 22 2022

8/22 – John Straub, Boston University

CBQB Seminar

August 22, 2022

12:00 PM - 1:30 PM


COMBR 7175 (in-person event)


909 S Wolcott Ave, Chicago, IL 60612

This is an in person event in room COMRB 7175 (909 S Wolcott Ave, Chicago, IL 60612 on west campus). You can also watch seminar live here>>

Speaker: Dr. John Straub
Professor, Boston University

Title: Probing the principles governing amyloid, protein aggregation and fibril formation

Abstract: Considerable progress has been made, using experiments and computations, to decipher the general principles governing the mechanism of formation of oligomers and fibrils of amyloid proteins implicated in diseases. The formation of amyloid aggregates is often observed to proceed from intrinsically disordered protein monomers to a highly ordered fibrillar state. Moreover, changes in sequence and environment may lead to a variety of polymorphs of the fibril state. I will discuss recent work exploring the connection between the conformational distribution of the monomeric protein and the ultimate fibril state. Examples will be taken from studies of amyloid-β protein (Aβ), associated with Alzheimer’s disease (AD), Fused in Sarcoma (FUS) protein, implicated in ALS and liquid-liquid phase separation, and Serum Amyloid A (SAA) protein, associated with AA amyloidosis.




UIC Biomedical Engineering

Date posted

Aug 15, 2022

Date updated

Aug 19, 2022