3/17 – Qing Nie, University of California, Irvine
CBQB Seminar (in-person event)
March 17, 2023
2:00 PM - 3:00 PM
This is an in-person event in room COMRB 8175 on west campus (directions). You can also watch seminar live here>>
Speaker:
Qing Nie, PhD
Chancellor's Professor
Director, The NSF-Simons Center for Multiscale Cell Fate Research
Department of Mathematics
Department of Developmental and Cell Biology
Department of Biomedical Engineering
University of California, Irvine
Title:
Multiscale spatiotemporal reconstruction of single-cell genomics data
Abstract:
Cells make fate decisions in response to dynamic environments, and multicellular structures emerge from multiscale interplays among cells and genes in space and time. The recent single-cell genomics technology provides an unprecedented opportunity to profile cells. However, those measurements are taken as static snapshots of many individual cells that often lose spatial information. How to obtain temporal relationships among cells from such measurements? How to recover spatial interactions among cells, such as cell-cell communication? In this talk I will present our newly developed computational tools that dissect transition properties of cells and infer cell-cell communication based on nonspatial single-cell genomics data. In addition, I will present methods to derive multicellular spatiotemporal pattern from spatial transcriptomics datasets. Through applications of those methods to systems in development and regeneration, we show the discovery power of such methods and identify areas for further development for spatiotemporal reconstruction of single-cell genomics data.
Date posted
Feb 7, 2023
Date updated
Feb 14, 2023