11/5 – Richard E. Waugh, University of Rochester
Biomedical Engineering Seminar
November 5, 2021
12:00 PM - 1:00 PM
Location
SEO 236
Address
851 S. Morgan St, Chicago, IL 60607, Chicago, IL 60612
Calendar
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Speaker: Richard E. Waugh, PhD
Professor, Department of Biomedical Engineering, University of Rochester
Title: Role of Cell Surface Mechanics in Leukocyte Adhesion
Abstract:
The interaction of leukocytes with the vascular endothelium is a central event in the immune response, and proper regulation of these interactions is critical to support robust host defense while avoiding inflammatory disease. These interactions take place in a complex mechanical environment, and mechanical forces have long been known to play an integral role in facilitating these interactions. In the seminar I will address the role that mechanical forces and cellular remodeling play in regulating leukocyte-endothelial interaction from two perspectives: one focusing on the role of leukocyte surface topography and the deformation or active remodeling of the leukocyte surface, and the other on the endothelial glycocalyx layer, including its mechanical properties and role as a barrier to unwanted adhesion. Both these mechanisms appear to make substantial contributions to the prevention of unwanted adhesion in the resting state, and both are substantially modified during the inflammatory response.
Date posted
Oct 27, 2021
Date updated
Nov 1, 2021