10/30 – Zhangli Peng, UIC
October 30, 2020
12:00 PM - 1:00 PM
Address
Chicago, IL 60612
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Title: Analytical and Computational Multiscale Models in Cell Mechanics
Abstract: While a cell is like a factory of chemical reactions, its structural components are crucial for its normal functions and survival. Molecular mutations of structural components can lead to altered mechanical properties and malfunction of the cell. Unlike hard materials used for buildings and cars, most structural components of the cell are soft and more complex. It is a grand challenge to predict analytically and computationally the mechanical behaviors of the cell due to its sophisticated mesoscopic structures, dynamic self-assembly, and strong entropic contributions to the free energy. In this seminar, I will talk about several analytical and computational multiscale models in cell mechanics we recently developed. I will introduce three analytical models, including 1) a 2D cytoskeletal network model [1] , which can be applied to nuclear lamina and cortex cytoskeleton, 2) an anisotropic shell model of microtubules and primary cilia [2], 3) an analytical solution of membrane tension of a growing cell embedded in a gel [3]. I will also present computational models of cell mechanics in microfluidic experiments, including 1) cells passing through submicron microfluidic slits [4], 2) inertial and viscoelastic microfluidic focusing of particles and cells [5].
[1] Feng, Waugh, Peng, Biophys J 2020.
[2] Flaherty, Feng, Young, Peng, Resnick, Biomech Model Mechanobiol, 2019.
[3] Wong, Bargi, Feng, Macaraniag, Lee, Peng, and Shin, Adv Science, 2020.
[4] Lu, Peng, Phys Fluids, 2019.
[5] Zhou, Peng, Papautsky, Microsyst Nanoeng, 2020.
Date posted
Sep 1, 2020
Date updated
Oct 26, 2020